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Acquire, analyze and share auscultation sounds: the ASAP project
Sandra Reichert1,2, Raymond Gass2, Amir Hajjam1, Abderrafiaa Koukam1, Gérard Nguyen3, Christian
Brandt4, Emmanuel Andres4
1SeT, UTBM, 90010 Belfort, France ([EMAIL], [EMAIL],
[EMAIL])
2Alcatel-Lucent, 1 route du Dr Albert Schweitzer, 67400 Illkirch, France ([EMAIL])
3Hôpital Avicenne, CHU Bobigny, 25 rue de Stalingrad, 93009 Bobigny, France
([EMAIL])
4Hôpital Civil, 1 place de l’hôpital, 67000 Strasbourg, France ([EMAIL],
[EMAIL])
ABSTRACT
Be able to distinguish and characterize abnormal auscultation sounds is important for an accurate medical diagnosis.
Even though several researches have been done on the analysis of auscultation sounds, today auscultation remains
subjective and difficult to share. In the context of the MERCURE telemedicine platform, we started a project called
ASAP. It deals in developing objective tools for the analysis of auscultation sounds and creating an auscultation sounds’
database in order to compare and identify the acoustical and visual signatures of the pathologies. Communication and
network technologies are fundame ntal elements to be able to collect, document, share and transmit, in real time or not,
auscultation sounds. Finally, the project aims at capitalizing of these new auscultation techniques around the creation of
a teaching unit: the Auscultation’s School.
Keywords: Auscultation’s School, pulmonary sound analysis, telemedicine platform
1
1 2009-CIE39-FR.
1. INTRODUCTION
To collect and analyse auscultation sounds, we propose
to put in place a new architecture (that will be described
more in details in paragraph 2 and figure 2). The collect
of the sounds is realized thanks to a wireless digit
stethoscope that communicates with a computing unit
through a Bluetooth Medical Device Area. The
computing unit can send the data through the network,
in order to store them, share them ( with a colleague for
a second opinion or with students for education); the
collected data will be used for the fundamental
researches that we started in the ASAP context. These
researches deal with pulmonary sound analysis and the
research of new markers characteristics in some specific
pathologies.
Actually, distinction between normal respiratory sounds
and abnormal ones (such as crackles, wheezes ) is
important for an accurate medical diagnosis.
Respiratory sounds include invaluable information
concerning the physiologies and pathologies of lungs
and airways obstruction. Thus, the spectral density and
amplitude of sounds can indicate the state of the lungs
parenchyma, the dimension of the airways and their
pathological modification [1].
Limits of human audition
Studies were performed in order to test the human’s ear
capability to detect crackles in an auscultation signal [2].
The methods used consist in simulated crack les
superimposed on real breath sound. The results indicate
that the most important detection errors are due to the
intensity of the respiratory signal, the type of crackles
and the amplitude of crackles. It can be inferred from
these studies that the vali dation of automatic crackles
detection algorithms should not take auscultation as
unique reference.
On the contrary, the understanding of mechanisms
linked to the creation of breath sounds is, for the
moment, imperfect. The recording and analysis of
respiratory sounds allow to improve this understanding
[3] and an objective relationship between abnormal
respiratory sounds with respiratory pathology. Besides,
an objective analysis allows to develop classification
systems [4] that make it possible to precisely qualify
normal and adventitious respiratory sounds. Whilst
conventional stethoscope auscultation is subjective and
hardly sharable, these systems should provide an
objective and early diagnostic help, with a better
sensitivity and reproducibility of the results.
Moreover, applications, including diagnosis
establishment, monitoring and data exchange through
Internet are obviously complementary tools to objective
and a utomatic auscultation sounds analysis. Sensors
devices will allow long duration monitoring for patient
at home or at hospital. It could also be a useful solution
for less -developed countries and remote communities
[5]. In addition, this type of system has the great
advantage to keep the non -invasive and less expensive
characteristics of auscultation.
Finally, Sestini and coll.’s studies [6] indicate that an
association between acoustical signal and its image is
beneficial to the learning and understanding for students
in medical science.
Definition of common markers
Nowadays, there are several definitions for the typical
markers of wheezes and crackles [7]. Thus, a universal
semantic has to be created. Several works [8] have
attempted to collect definitions of terms relating to
respiratory sounds and have arrived at a collection of
162 terms commonly used in the « Computer
Respiratory Sound Analysis » (CORSA). Nevertheless,
it still doesn’t allow physician to have a common
definition of terms that are used. For example, a wheeze
is still currently associated to a “whistling sound”, and a
crackle to “a sound of rice in a frying pan”.
Definition of semiology
The article of Rossi and coll. [9] gives
recommendations concerning the experimental
conditions required for recording respiratory sou nds. It
describes the optimal experimental conditions
(principally concerning background noise, including
sounds other than respiratory such as vocal sounds) and
the specific procedures according to the type of sounds
he wanted to record (breath, cough, snores), information
for the recording (diagnosis, evaluation of a therapy,
monitoring), the age of subject, and the recording
method (free field, endobronchial microphone). Lastly,
for short recordings, a sitting position is recommended,
but a lay position is preferably for long recordings.
2. ASAP : AN INNOV ATIVE E-HEALTH PROJECT
2.1 Context
ASAP or “ Analyse de Sons Auscultatoires et
Pathologiques” is a 3 -year-long French collaborative
project. It is part of a collaborative telemedicine
platform called « MERCURE » ( Mobile Et Réseau
pour la Clinique, l'Urgence ou la Résidence Externe ).
MERCURE (figure 1) deals with projects for remote
monitoring and clinical context thanks to modern tools
principally coming from the News Technologies of
Information and Communication.
Fig. 1. The MERCURE platform
STETAU is the first project of the MERCURE platform;
it aims at providing the patient and medical staff,
measurement tools that are non -invasive, mobile,
communicant and that allows to transmit vital
information by a secured way, objectively qualified by
signal processing tools. Thus, physicians will have
access to a tool for remote monitoring and exploration
of cardiac and pulmonary sounds. Besides, the proposed
tools will be made up of an enhanced graphical u ser
interface.
The ASAP project, that we will describe more in details
in the next paragraphs, deals with a worldwide database
for respiratory sounds, statistical analysis of
“pathological” sounds, search of new markers, set up of
a medical school for ausc ultation and a worldwide
experts network.
The EPIDAURE project deals with emergency care
services. The physician will be equipped with wireless
measurement tools that communicate with a processing
unit. It will allow him to have access to a first analysis,
a diagnosis help, and a transmission for remote second
analysis and saving in a patient database. In this project,
we will also work on a dedicated call center for
optimized handling of cars, specialists, tools and current
location that will lean on geo -localisation and
navigation.
MERCURE is a project inside the hospital for the
deployment of wireless measurement tools, notification
servers, voice/data/video transmission, voice over
WiFi/GSM with automatic handover, A -GPS and WiFi
localization of people, equipment, drugs, foods.
Finally, the last but not least project is REVES. It
emphasizes on a robot -friend for children with
leukaemia in sterile rooms. The robot-friend is a “new
multimedia terminal” equipped with a camera, a
microphone, loudspeakers, Wi Fi transmission,
geo-localization. It is connected to a call server plus
video server, notification, etc. This project is realized in
collaboration with teachers for the development of
content (educative tools, gaming), and with hospitals
practitioners (in tensive care unit) for pain stigma
detection.
2.2 Our value-added
Some projects or products already propose an evolution
of the stethoscope; we can quote in particular the
stethoscope Littmann or Jabes. Some firms propose as
well as their stethoscope, a CD-Rom with auscultation
sounds. Nevertheless, they only allow a basic
consultation with some examples, most theoretical, and
that are neither interactive nor a diagnosis support. In
addition, sounds are quite often synthetic sounds.
In the ASAP project, our ambition is not to propose a
stethoscope and to additionally provide sounds, but the
exact opposite. Indeed, we will propose a worldwide
sound database with visual and acoustical signatures,
that allow to consult and analyze sounds, perform
standard ex change of data. These sounds will, all the
more, be a support for learning auscultation. From
those data, a worldwide auscultation sounds database
will be created. It will list an important quantity of data
and will allow to create models or criteria to i mprove
detecting of pulmonary and cardiac diseases. Another
innovative aspect of our project is to make diagnosis
aid.
2.3 Description of the ASAP project
Auscultation is the first medical act that the medical
students can realise on patients; it is real ised empirically.
Our project proposes to introduce an evidence -based
medicine dimension at auscultation thanks to the
association with signal processing, visualisation and
archiving technologies. These new technologies will be
considered for the formation of the future physicians
and will be accessible through e-learning.
ASAP aims at making evolve the auscultation
techniques:
by the development objective tools for the
analysis of auscultation sounds : communicant
wireless electronic stethoscope paired wi th
computing device (like a PC or PDA) (figure
2);
Fig. 2. Remote auscultation
The physician can locally or remotely perform an
auscultation, see the auscultation sounds on his PC,
PDA or IP Phone; he can share it with students for
education, store it locally or in the hospital’s database.
by the creation of an auscultation sounds’
database in order to compare and identify the
acoustical and visual signatures of the
pathologies;
by the capitalisation of these new auscultation
techniques around the creat ion of a teaching
unit : « Ecole de l’Auscultation ». This
auscultation’s school will be destined to the
initial and continuous formation of the medical
attendants.
There are some major phases in the project (figure 3):
Fig. 3. ASAP project
The fi rst point is the definition of the relevant
semiology and thesaurus. It will allow to initialize a
platform for collecting, validating, storing respiratory
sounds.
The next point is the realisation of a worldwide
auscultation sounds database (WebSound) .
Then, health professionals and medical students could
use this database. The students would dispose of a
diversified palette of sounds via new technologies of
communication and information. It will allow to make
continuous formations related to specific pat hologies.
This will lead to the creation of the Auscultation’s
School.
Besides, in order to allow the connection of the
information systems of the hospitals, further work is
foreseen, to deal with the normalisation of the data
formats and semantic.
Afterwards, it will be possible to share auscultation
sounds between experts, thanks to a unified format. The
expert could discuss about a medical case, and refine the
diagnosis.
Finally, our project aims at initialising fundamental
research works for the definit ion of a visual and
acoustical signature of a pathology. The first
pathologies studied will be asthma, bronchitis, CODP
and cardiac pathologies. The aim is to make auscultation
more objective and intuit a pathology thanks to the
symptoms.
The success of t he projects is conditioned by the
definition of standard formats of the data and exchange
protocols.
Application domains
The applications can be telemedicine with local or
remote us. Several medical specialties will be interested
in such a tools, amon g remote monitoring for pat ients,
second opinion, teaching. We can quote:
Pneumology, for patients affected with
bronchiolitis, asthma, COPD, pneumopathy;
Cardiovascular; in particular V alvulopathy with
the diagnostic of heart murmurs, search of
additional sou nds and peripheral arterial
disease of the lower limbs, carotid stenosis;
Public health, for the prevention in school,
professional environment;
Gynecology obstetrics for prenatal auscultation
of the foetus health, teleconsultation of a
specialist;
V eterinary.
3. FIRST WORKS DEALING WITH THE
IDENTIFICATION OF MARKERS
In pulmonary sounds, known markers are crackles and
wheezes. The principal algorithm families of detection
of these markers are summarised in table 1.
TABLE I
THE PRINCIPAL ALGORITHM FAMILIES OF DETECTION OF THE KNOWN
MARKERS
SIGNAL CHARACTERISTICS
AND PROCESSING
[10]
ANALYSIS
Normal sounds
Lungs Low-pass filtering
(between 100 and
1000 Hz)
Periodogram (power spectral
density - PSD), auto -
regressive models [11]
Trachea Noise with
resonances [100,
3000 Hz]
Adventitious sounds
Wheezes Sinusoid (range ~
100 and 1000Hz;
duration > 80ms)
PSD, STFT(s hort-time Fourier
transform)[11], FFT, linear
prediction of coefficients [12],
genetic algorithms [13], neural
networks [13], wavelet [14]
Ronchus Series of sinusoid
(<300Hz and a
duration > 100ms)
Crackles Wave deflection
(duration typically
< 20ms)
Temporal analysis [11], FFT,
linear pr ediction of coefficients
[12], fuzzy non stationary filter
[12], genetic algorithms [13],
neural networks [13],
wavelet[15] [16]
Snores Temporal analysis, PSD [11]
Stridors PSD, STFT, auto reg ressive
models [11]
4. PERSPECTIVES: THE AUSCULTATION’S
SCHOOL
In a nutshell, it can be said that auscultation is an
individual act, difficult to share. On the contrary, the
Auscultation’s School will lean o n an objective
definition of the sounds useful for teaching and
diagnosis aid. Thanks to communications and network
technologies, the Auscultation’s School will have for
purpose to teach to student and professionals the new
innovative tools. In the same wa y, research programs
will try to detect new markers, detect pre -markers from
some pathologies…
The project begins by the scientific and clinical
validation of the service and ergonomic for several
pathologies: COPD, asthma, and bronchitis, and
cardiopathies. This step allows to collect auscultation
sounds that are characterized, documented and qualified.
The final goal is to create a worldwide referential
interconnected to medical study centres, pharmaceutical
research laboratories and auscultation sounds processing
systems.
Empirical methods provides already results to show the
value added of the analysis and the comparison of the
sounds for instance for the correlation between the
pulmonary blocking of a patient with cystic fibrosis
and the rate of detect ed crackles, the evolution of the
acoustic signature of a cardiac valve, ...
The main strengths of such a referential are:
improving the incontrovertible medical act that
is auscultation, by making it objective, and
factual, to share, histories and compar e the
data;
lean on the new technologies to push the
exploitation of auscultation sounds as a non
invasive exam and pertinent diagnosis aid and
local or remote monitoring;
create a new language exploitable by all the
profession.
The different constitutive parts of the Auscultation’s
School will be:
the good practices of auscultation : how to
auscultate, what are the abnormalities
researched;
the classical sounds in the various disciplines:
Cardiology, Pneumo logy, Paediatric,
Reanimation. The identification of crackles,
wheezes, and their correlation with the follow
up of a pathology;
the new auscultation tools: the digital
stethoscope, signal processing tools,
visualisation of the sounds and interpretation of
the obtained images;
the ongoing research project;
bibliographical references.
The access to the teaching could be initial for medical
students or ongoing training for experimented general
practitioners. Modern learning tools will be privileged.
This formation will be accessible by each medical
professional, and maybe more.
The first goal of such an initiative is the repositioning of
the auscultation as a fundamental non -invasive exam in
the medical diagnosis; while pushing to potentialities
thanks to the new technologies.
5. CONCLUSION
Today, prototypes of the digital stethoscope have been
tested by medical specialists. Algorithm have shown
definitive contribution to the improvement of the
auscultation act, in the context of the ASAP project. The
next step will consist in analysing deeper the sounds
with signal analysis techniques to allow the discovery of
new characteristic markers.
Real time remote auscultation, commented auscultation
sounds transfer, education became possible thanks to the
system we described.
Besides, we are working on protocols to transmit, in a
standardized way, auscultation data, associated with
comments and medical information.
Previous studies demonstrate the need of performing an
exhaustive scientific approach, that account of both the
definition of a semiology, the consolidation of definition
of known characteristics markers, the definition of
common or even universal semantics, the development
of determinist tools that will allow the detection of these
markers. It is precisely the context of an ambitious study
of in the so -called ASAP project. This study is handled
by a multidisciplinary team including medical from
CHRU of Strasbourg, IRCAD for web -based teaching
tools, Alcatel -Lucent research teams for the
development of the devices, tools, ergonomic,
algorithms and communic ation infrastructure. Among
the most identified outcome from the project, it is force
in to create auscultation school hosted by the ” Faculté
de Médecine” of Strasbourg (France).
ACKNOWLEDGEMENT
This work has been performed in the framework of the
projects from the platform MERCURE, and more
specifically especially the ASAP project. We would like
to acknowledge the partners of the project.
GRANT
ASAP project (ANR convention n° 2006 TLOG 21 04).
REFERENCES
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Chunks
| Chunk | Pages | Summary | Keywords | Questions |
|---|---|---|---|---|
| …_0 | p.1 | The ASAP project (Acquire, Analyze and Share Auscultation Sounds) builds tools and a database to collect, analyze... | 24 | 15 |
| …_1 | p.1–2 | The chunk discusses limits of current automatic detection of respiratory sounds—detection errors mainly stem from... | 45 | 16 |
| …_2 | p.2–3 | MERCURE (Mobile Et Réseau pour la Clinique, l'Urgence ou la Résidence Externe) is a collaborative telemedicine... | 48 | 20 |
| …_3 | p.2–3 | The chunk describes the ASAP project to modernize and teach auscultation by combining wireless electronic... | 33 | 15 |
| …_4 | p.3–4 | The text outlines efforts to make auscultation more objective and shareable through standard data formats and... | 65 | 20 |
| …_5 | p.4–5 | The project validates a clinical service and ergonomics for auscultation in pathologies such as COPD, asthma,... | 36 | 18 |
| …_6 | p.5 | This chunk describes an ambitious study within the ASAP project carried out by a multidisciplinary team (medical... | 21 | 10 |
| …_7 | p.5 | This chunk lists bibliographic references (1984–2005) about respiratory/breath sound recording and analysis,... | 34 | 11 |